Cannabinoids promote embryonic and adult hippocampus neurogenesis
We, and others, have shown that these newborn hippocampal neurons are functionally integrated into the existing neuroanatomical circuitry and are positively correlated with hippocampus-dependent learning and memory processes and the developmental mechanisms of stress and mood disorders. Chronic administration of the major drugs of abuse including opiates, alcohol, nicotine, and cocaine has been reported to suppress hippocampal neurogenesis in adult rats, suggesting a potential role of hippocampal neurogenesis in the initiation, maintenance, and treatment of drug addiction.
The subgranular zone of the dentate gyrus (SGZ) in the adult brain contains neural stem/progenitor cells (NS/PCs) capable of producing thousands of new granule cells per day.Chronic, but not acute, HU210 treatment promoted neurogenesis in the hippocampal dentate gyrus of adult rats and exerted anxiolytic- and antidepressant-like effects. suggesting that chronic HU210 treatment produces anxiolytic- and antidepressant-like effects likely via promotion of hippocampal neurogenesis.Introduction Cannabis (marijuana, hashish, or cannabinoids) has been used for medical and recreational purposes for many centuries and is likely the only medicine or illicit drug that has constantly evoked tremendous interest or controversy within both the public domain and medical research.Thus, cannabinoids appear to be the only illicit drug whose capacity to produce increased hippocampal newborn neurons is positively correlated with its anxiolytic- and antidepressant-like effects.
receptor/m TORC1-induced neural progenitor proliferation is relevant under physiological and pathological conditions such as cortical development and excitotoxicity-induced adult hippocampal neurogenesis.Most drugs of abuse examined to date decrease adult hippocampal neurogenesis, but the effects of cannabis (marijuana or cannabinoids) on hippocampal neurogenesis remain unknown.